Progress in research on regulation of tumor occurrence and development by forkhead box Q1 gene / 肿瘤

ABSTRACT

The transcription factor forkhead box Q1 (FOXQ1), a member of the forkhead box superfamily, is involved in various biological processes, and it also plays an important role in tumorigenesis and development. FOXQ1 protein activates the transcription by directly binding to the promoter of target genes or indirectly interacting with other transcription factors, and it affects initiation, progression, invasion and metastasis of tumor by promoting epithelial-mesenchymal transition (EMT) and activating multiple cellular signal transduction pathways. Previous studies have indicated that FOXQ 1 gene is significantly associated with the occurrence and development of a variety of tumors. The expression level of FOXQ 1 gene can be used as a prognostic indicator to judge the prognosis of various tumors. This review focuses on the possible mechanism of FOXQ 1 gene in tumorigenesis and development.