Progress in the chemoresistance mechanisms of bladder cancer / 肿瘤

ABSTRACT

In recent years, the appearance of tumor cell chemoresistance has brought new challenges to the treatment and prognosis of bladder cancer. Therefore, it is more and more urgent to study the chemoresistance mechanisms of bladder cancer. The current studies show that the chemoresistance mechanisms of bladder cancer mainly include drug efflux, epithelialmesenchemal transformation (EMT), cell autophagy, microRNA regulation and genetic epigenetic modification, which involves a variety of cell signal transduction pathways. Moreover, the different mechanisms of chemoresistance maybe have connections with each other by the same signaling pathways, thus forming a complex regulatory network. This paper reviews the latest progress in the study of chemoresistance mechanisms of bladder cancer, in order to provide new ideas for the targeted treatment of bladder cancer.