Expression of cyclase-Associated protein 1 in breast cancer tissues and its clinical significance / 肿瘤

ABSTRACT

Objective: To investigate the expression of cyclase-Associated protein 1 (CAP1) in breast cancer tissues and its clinical significance. Methods: Overall 93 specimens of breast cancer tissues and the paracancerous tissues were collected. The expressions of CAP1 and Ki-67 in breast cancer tissues and the para-cancerous tissues were detected by immunohistochemistry. The correlations of CAP1 with clinicopathological features and the prognosis were analyzed. Results: The expression levels of CAP1 and Ki-67 in breast cancer tissues were higher than those in the para-cancerous tissues (both P 0.05). There was a positive correlation between CAP1 expression and Ki-67 in breast cancer tissues (r 2 = 0.403, P = 0.002). The differentiation, axillary lymph node status, CAP1 expression and Ki-67 were independent prognostic factors of breast cancer (all P < 0.05). Conclusion: The expression of CAP1 is high in breast cancer tissues. CAP1 may play an important role in proliferation in breast cancer cells.