Effect of granulocyte colony-stimulating factor as prophylaxis on adjuvant chemotherapy-induced neutropenia in breast cancer patients receiving chemotherapy with epirubicin and cyclophosphamide / 肿瘤
Tumor
;
(12): 1239-1245, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-848643
ABSTRACT
Objective:
To compare the efficacy of pegylated recombinant human granulocyte colonystimulating factor (PEG-rhG-CSF) versus recombinant human granulocyte colony-stimulating factor (rhG-CSF) as prophylaxis of adjuvant chemotherapy (EC regimen Epirubicin combined with cyclophosphamide)-induced neutropenia in patients with breast cancer, and examine the safety.Methods:
A total of 135 breast cancer patients receiving adjuvant chemotherapy with EC regimen between October 2013 and March 2015 were divided into prophylactic group (n = 54) and non-prophylactic group (n = 81). The prophylactic group was further divided into PEG-rhG-CSF group (n = 19) and rhG-CSF group (n = 35). The PEG-rhG-CSF group was defined as being given PEG-rhG-CSF of single dose (3 mg) subcutaneously 48 hours after the end of the chemotherapy; the rhG-CSF group was defined as being given rhG-CSF 5 μg·kg-1·d- 1 subcutaneously 48 hours after the end of the chemotherapy and for 3-5 days.Results:
There were significant differences in the incidence rates of grade 3/4 neutropenia and febrile neutropenia (FN) between the prophylactic group and non-prophylactic group (both P 0.05).Conclusion:
Breast cancer patients receiving adjuvant chemotherapy with EC regimen should be prophylactically treated with G-CSF. PEG-rhG-CSF, which can prevent neutropenia effectively, is worth to be widely applied in clinical practice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tumor
Year:
2016
Type:
Article
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