Analysis of prognostic factors in 334 patients with renal cell carcinoma / 肿瘤

ABSTRACT

Objective: To analyze the factors affecting the prognosis of patients with renal cell carcinoma. Methods: The clinical records and follow-up information of 334 patients with primary renal cell carcinoma initially treated in Department of Urology, Tumor Hospital Affiliated to Xinjiang Medical University between January 2008 and December 2013 were collected. All the patients had complete clinical and follow-up information. The univariate analysis of prognostic factors was performed by Kaplan-Meier method. The multivariate analysis of prognostic factors was performed by COX regression model. Results: During follow-up, of 334 patients, 43 (12.9%) died of renal cell carcinoma and 69 (20.7%) developed recurrence and progression. The 1-, 3-, and 5-year survival rates of 334 patients were 95.2%, 86.3% and 83.6%, respectively. Five factors including serum calcium level, pathological type, TNM staging, tumor necrosis and venous tumor thrombus were independent prognostic factors (all P 0.05), as well as not significantly different between open surgery and laparoscopic surgery (P > 0.05). Conclusion: The main factors, which can influence the prognosis of patients with renal cell carcinoma, include serum calcium level, pathological type, TNM staging, tumor necrosis and venous tumour thrombus. The patients having poor prognostic factors should be treated with comprehensive treatment to increase the survival rate.