Association of CYP1A1z.ast;2C polymorphism with the susceptibility to childhood acute lymphoblastic leukemia: A meta-analysis / 肿瘤

ABSTRACT

Objective: To explore the contribution of cytochrome P450 (CYP) 1A1z.ast;2C polymorphism to susceptibility to acute lymphoblastic leukemia (ALL) in children. Methods: The case-control studies involving the association of CYP1A1z.ast;2C polymorphism with the susceptibility to childhood ALL were retrieved through computer-based search in PubMed, Embase, Ovid, China Journal Full-text Database, Chinese Biomedical Literature Data, China National Knowledge Infrastructure and Wanfang Database. The statistical analysis was performed by STATA 12.0 software. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated, and the subgroup ananlysis, sensitivity analysis and publication bias were also carried out. Results: A total of seven eligible case-control studies were included for analysis. The Meta analysis revealed that there was a significant association of CYP1A1z.ast;2C ploymorphism with risk of childhood ALL (C vs A OR = 1.20, 95% CI 1.01-1.43; GG vs AA OR = 1.73, 95% CI 1.1 1-2.70; GG vs AG + AA OR = 1.68, 95% CI 1.09-2.59). In a subgroup in which the controls were hospitalized in the same period as the cases hospitalized, there was also a significant association of CYP1A1z.ast;2C ploymorphism with risk of childhood ALL (G vs A OR = 1.29, 95% CI 1.04-1.59; GG vs AA OR = 1.89, 95% CI 1.15-3.10; GG vs AG+AA OR = 1.83, 95% CI 1.14-2.94). After excluding a study with high heterogeneity, the sensitivity analysis showed no significant association between CKP1A1z.ast;2C ploymorphism and childhood ALL. Conclusion: The results of this Meta analysis suggest that CYP1A1z.ast;2C polymorphism may be not significantly associated with the susceptibility to childhood ALL.