Association of CYP1A1z.ast;2C polymorphism with the susceptibility to childhood acute lymphoblastic leukemia: A meta-analysis / 肿瘤
Tumor
;
(12): 688-695, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-848694
ABSTRACT
Objective:
To explore the contribution of cytochrome P450 (CYP) 1A1z.ast;2C polymorphism to susceptibility to acute lymphoblastic leukemia (ALL) in children.Methods:
The case-control studies involving the association of CYP1A1z.ast;2C polymorphism with the susceptibility to childhood ALL were retrieved through computer-based search in PubMed, Embase, Ovid, China Journal Full-text Database, Chinese Biomedical Literature Data, China National Knowledge Infrastructure and Wanfang Database. The statistical analysis was performed by STATA 12.0 software. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated, and the subgroup ananlysis, sensitivity analysis and publication bias were also carried out.Results:
A total of seven eligible case-control studies were included for analysis. The Meta analysis revealed that there was a significant association of CYP1A1z.ast;2C ploymorphism with risk of childhood ALL (C vs A OR = 1.20, 95% CI 1.01-1.43; GG vs AA OR = 1.73, 95% CI 1.1 1-2.70; GG vs AG + AA OR = 1.68, 95% CI 1.09-2.59). In a subgroup in which the controls were hospitalized in the same period as the cases hospitalized, there was also a significant association of CYP1A1z.ast;2C ploymorphism with risk of childhood ALL (G vs A OR = 1.29, 95% CI 1.04-1.59; GG vs AA OR = 1.89, 95% CI 1.15-3.10; GG vs AG+AA OR = 1.83, 95% CI 1.14-2.94). After excluding a study with high heterogeneity, the sensitivity analysis showed no significant association between CKP1A1z.ast;2C ploymorphism and childhood ALL.Conclusion:
The results of this Meta analysis suggest that CYP1A1z.ast;2C polymorphism may be not significantly associated with the susceptibility to childhood ALL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Observational study
/
Risk factors
/
Systematic reviews
Language:
Chinese
Journal:
Tumor
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS