Advances in molecular targeted therapy for gastric cancer / 肿瘤

ABSTRACT

Chemotherapy-based comprehensive treatment is the main therapy for advanced gastric cancer (AGC). Although the signifcant progress has been made in the treatment of AGC, the standard first-line chemotherapy regimen for AGC remains controversy due to the low complete response rate of chemotherapy and the short duration of response after chemotherapy. In recent years, with the rapid development of tumor molecular biology, the understanding of various related molecular signaling pathways and the targeted molecules in the occurrence and development of gastric cancer has become clear, this has led to the development of new targeted molecular agents which targeting the critical aspects of oncogenic pathways.