Advances in relationship between PGC-1α and tumor metabolism / 肿瘤

ABSTRACT

The research on tumor metabolism has become a new hotspot in recent years, of which the key regulatory molecules that mediating tumor metabolism are a priority for all. The transcriptional co-activator peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1α) is one of these key regulatory molecules. PGC-1α has been demonstrated to be a crucial regulatory molecule involved in a variety of metabolic diseases. It is also a key molecule in regulation of tumor metabolism, mediating oxidative metabolism and anabolism to participate in regulation of survival, proliferation and migration of tumor cells. This paper reviews the advances in research on structure of PGC-1α and its related transcription molecules, and explores the mechanism of PGC-1α in regulation of occurrence and development of tumors, especially focuses on advances in the role of PGC-1α in tumor metabolism, which may provide theoretical references for fundamental studies on antitumor metabolism based on PGC-1α target as well as the related drug development.