Survival analysis of osteosarcoma patients with pulmonary metastasis undergoing different therapeutic methods / 肿瘤

ABSTRACT

Objective: To analyze the relationship between the prognosis and the different therapeutic methods in osteosarcoma patients with pulmonary metastasis. Methods: The clinical data of 87 osteosarcoma patients with pulmonary metastasis admitted in Sixth People's Hospital from January 2006 to August 2011 were retrospectively reviewed. All patients were followed up. According to the different therapeutic methods for the metastatic lung lesions, these 87 patients were divided into three groups surgery combined with chemotherapy group (21 cases), gamma-knife radiosurgery combined with chemotherapy group (26 cases), and chemotherapy alone group (40 cases). Kaplan-Meier method was used for survival analysis. The prognosis-related factors were analyzed by univariate and multivariate analyses. Results: The median progression-free survival (PFS) of patients in surgery combined with chemotherapy group or gamma-knife radiosurgery combined with chemotherapy group (8 months and 6 months) was longer than that in the chemotherapy alone group (3 months) (both P < 0.01). Three-year survival rates of osteosarcoma patients in surgery combined with chemotherapy group, gamma-knife radiosurgery combined with chemotherapy group, and the chemotherapy alone group were 38.10%, 30.77% and 12.50%, respectively. The unilateral or bilateral lung metastasis, initial treatment or retreatment, the number and distribution type of lung metastatic lesions, metastases of other sites (not lung), and the therapeutic methods for the lung lesions were correlated with prognosis (P < 0.05). The therapeutic method for lung metastatic lesions was an independent prognostic factor (P < 0.05). Conclusion: Chemotherapy combined with surgery or gamma-knife radiosurgery can effectively improve the survival of osteosarcoma patients with lung metastasis.