Protein O-GlcNAcylation and cancer / 肿瘤
Tumor
;
(12): 1027-1032, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-848946
ABSTRACT
O-GlcNAcylation is the addition of a single N-acetylglucosamine (GlcNAc) moiety to the hydroxyl groups of serine or threonine residues of nuclear and cytoplasmic proteins. O-GlcNAc plays an important role in the regulation of many biological processes including, but not limited to, cell cycle progression, transcription, translation, signal transduction, stress response, etc. O-GlcNAc plays significant roles in the progression and etiology of various diseases including diabetes, cardiovascular disease, cancer and Alzheimer's disease. The aberrant O-GlcNAcylation in tumor tissues is closely associated with cell proliferation and metastasis. This review is mainly involved the characteristics of protein O-GlcNAcylation alterations in different types of human cancer and the functions of O-GlcNAcylation in oncogenes and tumor suppressor genes. Copyright © 2013 by TUMOR.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tumor
Year:
2013
Type:
Article
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