Advances in research on the role of clusterin in treatment of human malignancies / 肿瘤

ABSTRACT

CLU (Clusterin) is an apoptosis-related protein which widely exists in human tissues and body fluids. It plays an important role in various pathophysiological processes including tissue remodeling, reproduction, lipid transport, complement regulation, and apoptosis. It was reported that CLU exerts a low expression level in normal and mature tissues while a high expression level in certain malignant tumors. CLU appears to have two main isoforms including secreted form and nuclear form. These two isoforms of CLU play different roles in human malignancies. Currently, more studies focused on treatment targeting CLU are going on. Copyright © 2013 by TUMOR.