The serum expressions of DKK-1 and DKK-3 in patients with prostate cancer and their clinical significance / 肿瘤

ABSTRACT

Objective: To investigate the expressions of serum DKK (Dickkopf)-1 and DKK-3 of Dickkopf family in patients with PC (prostate cancer) and the patients with BPH (benign prostatic hyperplasia). To explore the correlation of their expressions with the Gleason score and bone metastasis. Methods: Serum DKK-1 and DKK-3 levels in 40 patients with prostate cancer and 20 patients with BPH were detected by ELISA (enzyme-linked immunosorbent assay) and compared by using Spearman's correlation analysis to evaluate the intercorrelation of DKK-1 and DKK-3 expressions and their relationship with clinicopathological characteristics. The diagnostic performance of PSA (prostate specific antigen), DKK-1 and DKK-3 were determined by binary logistic regression method to draw the ROC (receiver operating characteristic) curves. Results: Serum DKK-1 and DKK-3 levels in patients with PC were significantly higher than those in patients with BPH. The serum DKK-1 level in PC with bone metastasis was higher than that in non-bone metastatic prostate cancer (P = 0.043). The predictive value of DKK-1 in diagnosing bone metastasis was slightly higher than PSA (P = 0.045). Serum DKK-3 level in high-risk PC with Gleason scores 8-9 was higher than that in moderate-risk PC with Gleason scores 6-7 (P = 0.036). The predictive value of DKK-3 in distinguishing the grade of cancer was higher than PSA (P = 0.039). There were no ralativeships between DKK-1 and bone metastasis, DKK-3 and Gleason grade, and DKK-1 and DKK-3. Conclusion: Serum DKK-1 and DKK-3 expressions are closely related to the occurrence of PC. DKK-1 may contribute to diagnose PC with bone metastasis. DKK-3 may support to distinguish the grade of PC. Copyright © 2013 by TUMOR.