Expression of aldehyde dehydrogenase 1 in human rectal carcinoma tissues and its prognostic significance / 肿瘤

ABSTRACT

Objective: To investigate the expression of CSC (cancer stem cell) and SC (stem cell) co-expressed marker ALDH1 (aldehyde dehydrogenase 1) in rectal carcinoma tissues and its clinical significance. Methods: The expressions of ALDH1 in rectal carcinoma tissues and the corresponding para-carcinoma tissues from 50 cases of rectal carcinoma were detected by indirect fluorescence antibody staining. The relationship between the expressions of ALDH1 and the clinicopathological features of patients with rectal carcinoma was analyzed. The five-year survival rate was estimated by Kaplan-Meier method. Results: The positive expression rate of ALDH1 in rectal carcinoma tissues was higher than that in the para-carcinoma tissues (P < 0.05). The expression level of ALDH1 was associated with tumor differentiation, Duke's stage, and TNM stage (P < 0.05). The five-year survival rate of patients with positive expression of ALDH1 was lower than that of patients without ALDH1 expression (P < 0.05). Conclusion: The expression of ALDH1 is associated with certain clinicopathological features and the five-year survival rate of patients with rectal cancer. Copyright © 2013 by TUMOR.