Influence of brown adipose tissue activity on 18F-FDG uptake in tumors / 肿瘤
Tumor
;
(12): 765-769, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-848980
ABSTRACT
Objective:
To evaluate the influence of BAT (brown adipose tissue) activity on 18F-FDG (18F-fluoro-2-deoxyglucose) uptake in tumors in cancer-bearing mice by using PET/CT (positron emission tomography/computed tomography) imaging.Methods:
The model of mice bearing NCI-H1299 human non-small cell lung cancer was established. The activity of BAT in mice was adjusted through regulating the experimental conditions. Two groups were designed in this study, including BAT-activation group (the activity of BAT in mice was stimulated by cold exposure and food diet during the period of 18F-FDG uptake) and BAT-inhibition group (the activity of BAT in mice was inhibited by fasting, anesthesia and heating). The mice were scanned with micro-PET/CT and the uptake of 18F-FDG in tumors in the two groups was analyzed and compared. The SUV (standard uptake value) was calculated.Results:
The tumor in BAT-activation group was nearly invisible on PET image and its 18F-FDG uptake value (SUV 0.15±0.06) was significantly lower than that in the BAT-inhibition group (SUV 0.58±0.20) (P < 0.05).Conclusion:
The enhancement of BAT activity will significantly decrease the uptake of 18F-FDG in tumors and influence the imaging of the tumors. Copyright © 2013 by TUMOR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tumor
Year:
2013
Type:
Article
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