The characteristics of microparticles derived from leukocytes of patients with breast cancer and their clinical significance / 肿瘤
Tumor
;
(12): 208-213, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-849098
ABSTRACT
Objective:
To explore the characteristics of leukocyte-derived microparticles (LMPs) in breast cancer patients and their clinical significance.Methods:
The expressions of LMPs, CD44+ LMPs, CD24+ LMPs and CD44+ CD24- LMPs in peripheral blood of 44 breast cancer patients and 10 healthy volunteers were detected by using flow cytometry. The percentages of CD44+, CD24+ and CD44+ CD24- cells in monocytes (MNCs) of breast cancer pateints and healthy volunteers were further detected. The clinical relevance of LMPs, and the correlation between MNCs and LMPs were analyzed.Results:
The percentages of LMPs, CD44+ LMPs and CD44+ CD24- LMPs in breast cancer patients were statistically higher than those in the healthy volunteers (P =0.021, P =0.011, and P =0.006, respectively). There was a statistical difference in the percentage of LMPs among the different tumor volunmes (P =0.018). Statistical difference was also obseved in the percentage of CD44+ LMPs among different Her-2 levels (P =0.020). The percentages of CD44+, CD24+ and CD44+ CD24- cells in MNCs in breast cancer patients were not statistically different from those in the healthy volunteers. There was no statistical correlation between MNCs and LMPs.Conclusion:
The percentage of LMPs in breast cancer patients can be used to evaluate the tumor volume. The percentage of CD44+ LMPs was closely correlated with Her-2 level, and it can be used to evaluate the recurrence, metastasis and prognosis of breast cancer. Copyright© 2012 by TUMOR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Tumor
Year:
2012
Type:
Article
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