Clinical analysis of 11 patients with bilateral primary breast lymphoma / 肿瘤

ABSTRACT

Objective: To investigate the clinicopathological features, treatment and prognosis of patients with bilateral primary breast lymphoma (BPBL). Methods: The clinical records of 11 patients with BPBL were collected, and the clinicopathological features, treatment and prognosis were retrospectively analyzed. Results: The medium age of 11 patients was 34 years old (ranged from 13 to 63 years). The breast tumors grew quickly, and the largest diameter of tumor was up to 20 cm. The occurrence of bilateral breast tumors was more often in synchronism than in heterochronism. The incidence rates of B symptoms and high level of serum LDH were both low in BPBL patients, and the axillary lymph node metastasis and distant metastasis were frequent. The BPBL was originated mainly from B cells, and the most common pathological grade of BPBL was grade high/intermediate. The median survival of BPBL was 33 months. Furthermore, chemotherapy played an important role in the treatment of BPBL. Conclusion: In consideration of BPBL which has a high rate of diagnostic errors, the clinicopathological features and medical imagings should be applied in the diagnosis of BPBL. The major modality used in the treatment of BPBL is chemotherapy. Copyright© 2011 by TUMOR.