Chemokine CCL20 and malignant tumors / 肿瘤
Tumor
;
(12): 961-963, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-849160
ABSTRACT
Chemokine is a kind of cytokine that induces cell transport to inflammation sites. It plays an important role in controlling the differentiation, development and directed migration of immunocytes. CCL20 is one of the important members of chemokine family, and it belongs to CC subfamily. Its receptor is CCR6. CCL20 can be expressed in activated monocytes, T lymphocytes, dendritic cells and endothelial cells, and CCR6 can be expressed in liver, lung, and lymphoid tissues. The expression of CCL20 can be induced by tumor necrosis factor α (TNFα), interleukin 1β (IL-1β), IL-17, CD40 ligand and interferon γ (IFN-gamma;). In summary, CCL20 plays an important role in tumor growth, invasion and metastasis (mainly refers to intrahepatic metastasis). Copyright© 2011 by TUMOR.
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tumor
Year:
2011
Type:
Article
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