Role of18F-FDG PET/CT in preliminary diagnosis and postoperative surveillance for uterine cervical cancer / 肿瘤

ABSTRACT

Objective: To evaluate the clinical value of 18F- fluorodeoxyglucose (FDG) positron-emission tomography (PET)/CT in preliminary diagnosing and postoperative monitoring for cervical cancer. Methods: A retrospective review was performed in 72 patients with uterine cervical diseases, and all patients were evaluated with PET/CT. They were divided into two groups the preliminary diagnosing group, in which 43 cervical cancer-equivocal patients underwent PET/CT for diagnosis and staging; the postoperative monitoring group, in which 29 patients underwent PET/CT for monitoring recurrence or metastasis after chemoradiotherapy or operation. Finally, the results of PET/CT imaging were proved by biopsy, pathology and other examinations or clinical follow-up. The clinical follow-up is longer than 6 months. Results: For preliminary diagnosing and staging of the cervical cancer, the sensitivity, specificity and the accuracy of PET/CT were 83.8% (31/37), 50.0% (3/6) and 79.1% (34/43), respectively; among the 31 patients with cervical cancer, 12 (38.7%) had lymph node metastasis. In the postoperative monitoring group, 11 patients had metastatic lesions. The sensitivity, specificity and the accuracy of PET/CT to detect the metastasis were 100% (11/11), 77.8% (14/18) and 86.2% (25/29), respectively. Among the 11 patients, 5 (45.5%) patients were found to have small lymph node metastasis. Conclusion: 18F-FDG PET/CT imaging can increase the accuracy of diagnosis and staging of cervical cancer, and it is useful to make the more reasonable treatment plans and the postoperative monitoring procedures. Copyright© 2011 by the Editorial Board of Tumor.