The clinical application of permanent implantation of iodine 125 seeds for osseous metastases / 肿瘤

ABSTRACT

Objective: To evaluate the clinical efficacy of permanent implantation of iodine 125 seeds in the treatment of osseous metastases. Methods: Radioactive iodine 125 seeds were implanted permanently in 52 lesions of forty patients with osseous metastases of different origins. The ostalgia-relieving degree and the imaging alterations of the osseous metastasis lesions were observed. Results: The effective pain-relieving rate was 92.5% (37/40) caused by permanent implantation of iodine 125 seeds. Of all the patients, 23 patients achieved complete response, 14 patients obtained partial response (PR), and 3 patients had no change. The total effective rate was 92.5%. The pain grade was decreased significantly after the treatment (P <0.05). Imaging examination showed that 12 lesions had partial response, 32 lesions had stable disease, and 8 lesions had progressive disease at 2 months after surgery. All the patients had no serious adverse reactions. Conclusion: Permanent implantation of 125I seeds has a definite effects on tumor metastasis and caused minimal damage and few complications. It is worthy of popularization in clinic.