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A case-control study on the associations of ER codon 325 and PR +331G/A with the risk of breast cancer / 肿瘤
Tumor ; (12): 859-863, 2008.
Article in Chinese | WPRIM | ID: wpr-849286
Responsible library: WPRO
ABSTRACT

Objective:

To investigate the association of estrogen receptor (ER) codon 325 and progestin receptor (PR) +331G/A gene with the risk of breast cancer and the influence of the two genes combined with the environmental risk factors on breast cancer.

Methods:

A case-control study was performed. Two hundred and six cases with newly diagnosed breast cancer were collected. Two hundred and fourteen healthy women were matched according to age frequency (± three years). The epidemiological data were collected by questionnaire using structured tables. The 3 mL venous blood was collected and the genotypes of ER codon 325 and PR + 331 G/A were determined by fluorescent quantitative PCR.

Results:

Compared with CC, the adjusted OR was 0.99 (95% CI 0.61-1.61) and 1. 13 (95% CIO. 62-2. 04) for CG genotype and GG genotype of ER-codon 325, respectively. The adjusted OR was 1.51 (95% CI 0.74-3.07) for GG genotype of PR + 331 G/A. No synergistic effects of ER codon 325 and PR + 331 G/A were observed in increasing the risk of breast cancer (Trend analysis, P = 0.409). The adjusted OR was 3.57 (95% CI 1. 21-10. 52) for the ER codon 325 CG- and GG-genotyped women with spontaneous abortion history compared with that in CC-genotyped women without spontaneous abortion history. Additive models test demonstrated that the difference tended to be significant (S = 3.06, AP = 0.97, u = 1.898 1 , P = 0.058 8).

Conclusion:

The single nucleotide polymorphism (SNP) of ER codon 325 and PR + 331 G/A genes are not associated with the risk of breast cancer. The SNP of ER codon 325 with spontaneous abortion history tends to synergistically increase the risk of breat cancer.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Tumor Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Tumor Year: 2008 Type: Article