The combined multifold therapy for bronchostenosis induced by esophagus cancer / 肿瘤

ABSTRACT

Objective: To explore an ideal method and evaluate its clinical outcome in treating bronchostenosis induced by esophagus cancer. Methods: All cases were given argon plasma coagulation therapy to widen their trachea and shrink the focus area in terms of the invasion site and severity of trachea. Then some of them were placed with membrane-covered trachea brackets or given photodynamic therapy. Finally all the patients received bronchial artery embolizing chemotherapy to enhance the therapeutic efficacy. Results: Among the 23 cases treated with argon plasma coagulation (APC) therapy, 4 patients who did not receive any other treatment died within 58 days. The six patients who were placed trachea brackets only lived a period of 98 days on average. Seven patients who were placed trachea brackets and given bronchial artery embolizing chemotherapy lived a period of 166 days on average. Among the rest 6 cases who were cured with photodynamic therapy plus bronchial artery embolizing chemotherapy, 2 suffered from trachea-esophagus fistula 1-2 month later after leaving hospital and membrane-covered trachea brackets had to be rearranged. One died of severe emptysis 126 d later. The patients were followed up until November 30, 2007. The survival period in 2 cases was over 180 d, in 2 cases over 220 days, and in 1 case over 240 d. The mean survival time was 198 d during follow-up period. Conclusion: The combined multifold sequential therapy guided by endoscope is an ideal method to cure bronchostenosis induced by esophagus cancer. It is worthy of further studying and publicizing.