The individuals with rs224175 T/T genotype of the TGF-Β1 gene have an increased risk for developing IIBV infecton-associated diseases / 肿瘤
Tumor
;
(12): 502-505, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-849354
ABSTRACT
Objective:
To assess the association of three new single nucleotide polymorphism (SPN) sites of the transforming growth factor β1 (TGF-β1) gene, which is prevalent in Asia, with the susceptibility to the chronic hepatitis B infection-related liver disease.Methods:
The genomic DNA of 129 cases suffering from the chronic HBV peripheral blood infection (74 cases with chronic type B hepatitis, 41 cases with liver cirrhosis and 14 cases with liver cancer) as well as 41 healthy volunteers were prepared. The genotypes of the TGF-β1 gene at rs2241715, rs2241716 and rs4803455 sites were detected by an allotype-specific PCR method.Results:
There was a significant difference in the genotypes for rs2241715 and allele frequencies between healthy volunteers and patients with chronic type B hepatitis, liver cirrhosis, and liver cancer (P < 0.05). The individuals with rs2241715 T/T genotype had a 2.974-fold increased risk for developing chronic type B hepatitis (95% CI = 1.209-7.314, P =0.018) and 3.228-fold increased risk for developing liver cirrhosis (95% CI = 1.201-8.675, P = 0.020), while no significant correlation was observed in both genotypes and allele frequencies at rs2241716 and rs4803455 sites.Conclusion:
The TGF-β1 rs2241715 T/T genotype a predisposing factor for the chronic HBV infection-related diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
Language:
Chinese
Journal:
Tumor
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS