Intracavitary infussion of Huachansu injection combined with polysaccharide nucleic acid fraction of Bacillus Calmette Guérin (BCG-PSN) or cisplatin in the treatment of malignant pleural and peritoneal effusions / 肿瘤
Tumor
;
(12): 517-519, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-849357
ABSTRACT
Objective:
To study the effect of intracavitary infusion of Huachansu injection combined with polysaccharide nucleic acid fraction of Bacillus Calmette Guérin (BCG-PSN) or cisplatin in the treatment of the malignant pleural and peritoneal effusions.Methods:
Seventy patients were randomly divided into two groups. Patients in the treatment group (n = 35) were intracavitarily infused with 20 mL of Huachansu injection and 18 mL of BCG-PSN; patients in the control group (n = 35) were intracavitarily infused with 20 mL of Huachansu injection and 60 mg of cisplatin once a week and the treatment lasted for 2-4 weeks.Results:
For the treatment group, the response rate (complete response + partial response) was 83.3% in 24 cases with malignant pleural effusion and 63.6% in 11 cases with malignant peritoneal effusion. The total response rate was 77.1% (27/35) in the treatment group. The KPS score was elevated in 26 cases, stable in 7 cases, and decreased in 2 cases. For the control group, the response rate (complete response + partial response) was 86.4% in 22 cases with malignant pleural effusion and 69.2% in 13 cases with malignant peritoneal effusion. The total response rate was 80.0% (28/35). The KPS score was increased in 16 cases, stable in 11 cases, and decreased in 8 cases. There was no significant difference in clinical efficacy between the two groups (P > 0.05). Patients in the treatment group had less adverse reaction and a more improved living quality than those in the control group (P < 0.05).Conclusion:
Intracavitary infusion of Huachansu injection combined with BCG-PSN or cisplatin was effective in the treatment of malignant pleural and peritoneal effusions, but Huachansu injection plus BCG-PSN had less toxicity especially for the advanced patients who can not tolerate the intracavitary chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tumor
Year:
2008
Type:
Article
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