Investigation on the nutrition status of 132 advanced lung cancer patients in primary treatment / 肿瘤

ABSTRACT

Objective: To investigate the nutrition status of lung cancer patients in stage III and IV who were admitted in hospital and receive primary treatment. Methods: One hundred and thirty two lung cancer patients and 38 benign lung disease patients were prospectively investigated using patient generated-subjective global assessment (PG-SGA). Body mass index (BMI), total lymphocyte count, hemoglobin, serum albumin, iron transferring protein, pre-albumin, LDH, fasting glucose, cholesterol, triglycerides, blood urea nitrogen and creatinine levels were detected. Results: There were 19(14%) lung cancer patients in grade A, 51(39%) in grade B and 60(47%) in grade C based on PG-SGA score. Seventy two patients (54.5%) had PG-SGA score at 2 to 8 and 57 (42.2%) lung cancer patients had PG-SGA score ≥9, and only 3(2.3%) lung cancer patients had PG-SGA score between 0 to 1. The ratio of lung cancer patients in grade C was significantly higher than benign lung disease patients. In lung cancer patients at stage III and IV, BMI and serum albumin were significantly different between A, B and C 3 grades; age of patients and hemoglobin level were significantly different between B and C 2 grades. The chemotherapy-induced bone marrow suppression correlated with the number of combined drugs. Conclusion: The admitted lung cancer patients at stage III and IV had high protein-energy malnutrition rates. There was good consistency between PG-SGA score and traditional nutritional assessment indicated by BMI, serum albumin, and hemoglobin.