Expressions of EphA 2 and KAI 1 in human bladder transitional cell carcinoma and its significance / 肿瘤

ABSTRACT

Objective: To investigate the association of EphA 2 and KAI 1 protein expressions with the occurrence, invasion, and metastasis of bladder transitional cell carcinoma tissues (BTCC). Methods: The expressions of EphA 2 and KAI 1 proteins were determined by immunohistochemical SP method in 88 cases of BTCC tissues and 76 cases of pericancerous normal bladder tissues. Results: The expression of EphA 2 protein was significantly higher in BTCC tissues than in adjacent normal tissues (P < 0.01). The expression of EphA 2 protein was gradually increased with the elevation of pathological grades of BTCC. The positive rate of EphA 2 expression was significantly higher in deeply infiltrating BTCC than superficially infiltrating BTCC (P < 0.05). It was significantly higher in the group with lymph node metastasis than those without lymph node metastasis (P < 0.05). The expression of KAI 1 protein was significantly lower in BTCC tissues than in adjacent normal tissues (P < 0.01). The expression of KAI 1 was gradually decreased with the elevation of pathological grades of BTCC. The positive rate of KAI 1 expression was significantly lower in deeply infiltrating BTCC than in superficially infiltrating BTCC (P < 0.05). It was significantly lower in the BTCC with lymph node metastasis than those without lymph node metastasis (P < 0.05). A significantly negative correlation was observed between the expression of EphA 2 and that of KAI 1 in BTCC tissues with lymph node metastasis (P < 0.05). Conclusion: Overexpression of EphA 2 and weak expression of KAI 1 may be involved in the tumorigenesis, infiltration, and migration of BTCC.