Expressions of EphA 2 and KAI 1 in human bladder transitional cell carcinoma and its significance / 肿瘤
Tumor
;
(12): 142-145, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-849425
ABSTRACT
Objective:
To investigate the association of EphA 2 and KAI 1 protein expressions with the occurrence, invasion, and metastasis of bladder transitional cell carcinoma tissues (BTCC).Methods:
The expressions of EphA 2 and KAI 1 proteins were determined by immunohistochemical SP method in 88 cases of BTCC tissues and 76 cases of pericancerous normal bladder tissues.Results:
The expression of EphA 2 protein was significantly higher in BTCC tissues than in adjacent normal tissues (P < 0.01). The expression of EphA 2 protein was gradually increased with the elevation of pathological grades of BTCC. The positive rate of EphA 2 expression was significantly higher in deeply infiltrating BTCC than superficially infiltrating BTCC (P < 0.05). It was significantly higher in the group with lymph node metastasis than those without lymph node metastasis (P < 0.05). The expression of KAI 1 protein was significantly lower in BTCC tissues than in adjacent normal tissues (P < 0.01). The expression of KAI 1 was gradually decreased with the elevation of pathological grades of BTCC. The positive rate of KAI 1 expression was significantly lower in deeply infiltrating BTCC than in superficially infiltrating BTCC (P < 0.05). It was significantly lower in the BTCC with lymph node metastasis than those without lymph node metastasis (P < 0.05). A significantly negative correlation was observed between the expression of EphA 2 and that of KAI 1 in BTCC tissues with lymph node metastasis (P < 0.05).Conclusion:
Overexpression of EphA 2 and weak expression of KAI 1 may be involved in the tumorigenesis, infiltration, and migration of BTCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Tumor
Year:
2008
Type:
Article
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