Expressions of calcineurin A and B in breast carcinoma tissues / 肿瘤

ABSTRACT

Objective: To investigate the expression of calcineurin (CaN) in breast carcinoma and to analyze the relationship between the expression of the member of CaN family and clinicopathological features. Methods: The expressions of CaN Aα, CaN Aβ and CaN B in 55 cases of breast carcinoma tissues and adjacent normal tissues were measured by Western blotting. The intracellular distribution of CaN proteins were detected by immunohistochemical method. Results: The expression levels of CaN Aα and CaN Aβ and CaN B proteins were markedly increased in breast carcinoma tissues compared with adjacent normal tissues. The relative intensities were 6.45-,4.67-, and 2.31-fold of the control group, respectively (P < 0.05). The expression levels of CaN Aα and CaN Aβ were related with TNM staging (III/IV) of breast carcinoma (P = 0.05). Conclusion: The continuous activation of CaN signaling pathway maybe play an important role in tumorigenesis of breast carcinoma.