Correlation of TFPI-2 gene expression with invasion, metastasis, and prognosis of supraglottic carcinoma / 肿瘤
Tumor
;
(12): 40-43, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-849440
ABSTRACT
Objective:
To investigate the relationship between TFPI-2 gene expression and the invasion, metastasis, and prognosis of supraglottic carcinoma.Methods:
Reverse transcriptase polymerase chain reaction and immunohistochemical methods were used to examine the expression of TFPI-2 in supraglottic carcinoma, and the relationship between TFPI-2 expression and the clinicopathological features of supraglottic carcinoma were analyzed.Results:
Positive ratio of TFPI-2 expression was significantly increased at protein and mRNA levels in supraglottic carcinoma tissues (P < 0.05). TFPI-2 mRNA and protein expression were decreased with the increase in the invasive depth of supraglottic carcinoma (P < 0.05). TFPI-2 mRNA and protein expression were significantly lower in supraglottic carcinoma tissues with nodal metastasis and at III-IV clinical stage than those without nodal metastasis and at I - II clinical stage (P < 0.05). The staining intensity of TFPI-2 protein was also decreased with increase in invasive depth and nodal metastasis (P < 0.05). The supraglottic carcinoma patients with negative TFPI-2 protein expression had poor prognosis than those with positive TFPI-2 expression.Conclusion:
The downregulation of TFPI-2 has a close relationship with invasion and metastasis of supraglottic carcinoma, and it may serve as a helpful marker in evaluating the metastasis and prognosis of supraglottic carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Tumor
Year:
2008
Type:
Article
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