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Correlation of TFPI-2 gene expression with invasion, metastasis, and prognosis of supraglottic carcinoma / 肿瘤
Tumor ; (12): 40-43, 2008.
Article in Chinese | WPRIM | ID: wpr-849440
ABSTRACT

Objective:

To investigate the relationship between TFPI-2 gene expression and the invasion, metastasis, and prognosis of supraglottic carcinoma.

Methods:

Reverse transcriptase polymerase chain reaction and immunohistochemical methods were used to examine the expression of TFPI-2 in supraglottic carcinoma, and the relationship between TFPI-2 expression and the clinicopathological features of supraglottic carcinoma were analyzed.

Results:

Positive ratio of TFPI-2 expression was significantly increased at protein and mRNA levels in supraglottic carcinoma tissues (P < 0.05). TFPI-2 mRNA and protein expression were decreased with the increase in the invasive depth of supraglottic carcinoma (P < 0.05). TFPI-2 mRNA and protein expression were significantly lower in supraglottic carcinoma tissues with nodal metastasis and at III-IV clinical stage than those without nodal metastasis and at I - II clinical stage (P < 0.05). The staining intensity of TFPI-2 protein was also decreased with increase in invasive depth and nodal metastasis (P < 0.05). The supraglottic carcinoma patients with negative TFPI-2 protein expression had poor prognosis than those with positive TFPI-2 expression.

Conclusion:

The downregulation of TFPI-2 has a close relationship with invasion and metastasis of supraglottic carcinoma, and it may serve as a helpful marker in evaluating the metastasis and prognosis of supraglottic carcinoma.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Tumor Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Tumor Year: 2008 Type: Article