The role of MTA1 protein in the invasion and metastasis of breast cancer / 肿瘤

ABSTRACT

Objective: To investigate the relationship between metastasis-associated gene 1 (MTA1) expression and the biological behaviors on human breast cancer. Methods: SP immunohistochemical technique was used to detect the expression of MTA1 protein among 116 human breast cancer samples and matched normal breast tissues. Results: (1) The expression of MTA1 was significantly higher in the breast cancer tissues than those of matched normal breast tissues (70.7% vs 10.3%, P < 0.05). (2) MTA1 protein had significantly higher expression in grade III-IV, low-differentiated, and axillary lymph node metastatic breast cancer tissues than those at grade I-II, high or middle differentiated, and without axillary lymph node metastasis (P < 0.05). Conclusion: There is a positive association between the expression of MTA1 and clinical stage, histological grade, and lymph node metastasis of breast cancer. MTA1 is a metastasis-facilitated protein and can be used as a prognostic marker for detection of recurrence and metastasis of breast cancer.