Clinical observation on early intraperitoneal hyperthermic perfusion chemotherapy in the treatment of stomach carcinoma after operation / 肿瘤

ABSTRACT

Objective: To study the clinical effect of early intraperitoneal hyperthermic perfusion chemotherapy on stomach carcinoma after operation. Methods: A total of 78 patients with stomach carcinoma were randomly divided into two groups. The therapeutic group received an intraperitoneal hyperthermic perfusion chemotherapy combined with intravenous chemotherapy (n = 41). The control group were given the intravenous chemotherapy only (n = 37). Postoperative complications, adverse reaction, local recurrence, distant metastasis, and 1- and 3-year survival rate were compared between the two groups. Results: There was no significant difference in the postoperative complications and adverse reaction between the two groups. The local recurrence rate and distant metastasis rate in the therapeutic group were significantly lower than the control group (21.95% vs 40.54%, 17.07% vs 37.83%, P < 0.05). The 1-year and 3-year survival rate in the therapeutic group were higher than the control group (90.24% vs 81.68%, 68.29% vs 48.64%, P < 0.05). Conclusions: Early postoperative intraperitoneal hyperthermic perfusion chemotherapy, effectively decreased the rate of local recurrence and distant metastasis and increased the survival rate. It is safe and easy to operate.