Research progress in the treatment of disc degeneration by bone marrow mesenchymal stem cells and their exocrine / 解放军医学杂志

ABSTRACT

Bone marrow mesenchymal stem cells (BMSCs) are multi-directional cells with self-renewal and differentiation into multiple types of cells, which play an important role in tissue healing and regenerative medicine. BMSCs can repair intervertebral disc degeneration (IDD) by promoting cell proliferation and expressing extracellular matrix components similar to intervertebral disc type Ⅱ collagen, proteoglycan, etc., and be expected to delay or even reverse the IDD from etiological level, but certain limitations existed. Recent studies have found that exosomes secreted by BMSCs can inhibit the apoptosis of nucleus pulposus cells through intercellular communication and slow down the occurrence of IDD. It possesses greater therapeutic advantage and is a new breakthrough in the treatment of IDD. In present paper, the latest research results have been elaborated of BMSCs and their secreted exosomes in IDD, in order to be better applied to clinical treatment.