Hypothalamus-Pituitary-Adrenal Axis Hypersuppression Is Associated with Gastrointestinal Symptoms in Major Depression
Journal of Neurogastroenterology and Motility
;
: 292-303, 2016.
Article
in English
| WPRIM
| ID: wpr-84968
ABSTRACT
BACKGROUND/AIMS:
Gastrointestinal symptoms and hypothalamus-pituitary-adrenal (HPA) axis dysfunction are frequently observed in patients with major depression. The primary aim of the study was to investigate the relationship between HPA-axis function and self-perceived functional gastrointestinal symptoms in major depression.METHODS:
Patients with major depression (n = 73) and controls representative of the general population (n = 146) underwent a weight-adjusted very low dose dexamethasone suppression test (DST). Patients and controls completed the gastrointestinal symptom rating scale-iritable bowel syndrome (GSRS-IBS) and the hospital anxiety depression scale. Medical records of the patients were screened over a ten year period for functional gastrointestinal disorder and pain conditions.RESULTS:
Patients with high GSRS-IBS scores (above median) exhibited HPA-axis hypersuppression more often than controls (defined by the lowest 10% cutoff of the post-DST cortisol values among controls, adjusted OR 7.25, CI 1.97-26.7) whereas patients with low GSRS-IBS scores did not differ from controls concerning their post-DST cortisol values. Patients who had consulted primary care for functional gastrointestinal disorder (P = 0.039), lumbago (P = 0.006) and chronic multifocal pain (P = 0.057) also exhibited an increased frequency of hypersuppression.CONCLUSIONS:
HPA-axis hypersuppression is associated with functional gastrointestinal symptoms in patients with major depression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Primary Health Care
/
Axis, Cervical Vertebra
/
Dexamethasone
/
Hydrocortisone
/
Medical Records
/
Low Back Pain
/
Irritable Bowel Syndrome
/
Depression
/
Gastrointestinal Diseases
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2016
Type:
Article
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