Action nechanism of Notch signaling pathway in pancreatic inflammation and tumor progression / 解放军医学杂志

ABSTRACT

Notch signaling pathway is a group of trans-membrane proteins that can regulate development and differentiation cells. It is highly conserved in evolution. Notch signaling pathway plays an important role in the early development of the pancreas, and also shows significant activation in the progression of pancreatitis and pancreatic cancer. Rational regulation of Notch signaling pathway may provide a new insight into the diagnosis and treatment of pancreatic exocrine diseases. This review focuse on role of Notch signaling pathway in the development and progression of pancreatitis and pancreatic cancer.