Correlation of plasma level of MNs to blood lipid, blood glucose and blood pressure in patients with pheochromocytoma/paraganglioma / 解放军医学杂志

ABSTRACT

Objective To investigate the correlations of plasma methoxyadrenaline (MN) and methoxynorepinephrine (NMN) (collectively called MNs) to blood lipid, blood glucose and blood pressure in patients with pheochromocytoma (PCC) and paraganglioma (PGL) (collectively called PPGL). Methods The clinical data were retrospectively analyzed of 64 patients with pathologically confirmed PPGL in Chinese PLA General Hospital during Jan. 2017 to Jun. 2018. According to the tertiles plasma MN before operation, the 64 cases were divided into T1 (n=21), T2 (n=21) and T3 (n=22) group, and then were divided into T’1 (n=21), T’2 (n=21) and T’3 (n=22) group according to the tertiles plasma NMN before operation. The correlations were analyzed of plasma level of MNs to the blood lipid, blood glucose and blood pressure. Results The body mass index (BMI) value decreased significantly with the increase of plasma MNs level in patients with PPGL. With the increase of plasma NMN level, high density lipoprotein cholesterol (HDL-C) and systolic blood pressure (SBP) increased significantly (P<0.05). Pearson correlation analysis showed that the plasma MN was negatively correlated with BMI (r=-0.319, P=0.010), and positively correlated with the tumor diameter (r=0.268, P=0.032). The plasma NMN was negatively correlated with BMI (r=-0.353, P=0.004), and positively correlated with SBP, fasting blood glucose (FBG), total cholesterol (TG), HDL-C, and tumor diameter (r=0.256, 0.019, 0.047, 0.001 and 0.003, respectively. P<0.05). The multivariate linear regression analysis showed that the plasma MN was negatively correlated with BMI (β=0.09, P=0.004) and positively correlated with tumor diameter (β=0.04, P=0.016). Plasma NMN was negatively correlated with BMI (β=0.08, P=0.006), and positively correlated with SBP, FBG, TG, HDL-C, tumor diameter (β=0.01, 0.13, 0.18, 0.50 and 0.06, respectively. P<0.05). Conclusions The plasma MNs level is related to the regulation of blood lipid, blood sugar and blood pressure. Patients with high plasma MNs level before operation should pay more attention to the occurrence of hypertension and high FBG.