The relationship between serum Golgi protein 73 and both liver inflammation and fibrosis in patients with chronic hepatitis B / 解放军医学杂志

ABSTRACT

Objective To explore the correlation between serum Golgi protein 73(GP73) and both liver inflammation and fibrosis in patients with chronic hepatitis B(CHB). Methods Altogether 322 patients who underwent liver biopsy were enrolled in this retrospective study, and GP73, ALT, AST, LSM, FIB-4, APRI were analyzed. The relationship between serum GP73 and both liver inflammation and fibrosis was analyzed. Univariate and multivariate logistic regression analysis were used to evaluate the predictive value of GP73 for significant liver injury. Results 322 CHB patients ranged from 18 to 66 years old, including 231 males (71.7%) and 91 females (28.3%), and the median of GP73 was 65.6(35.8-129.6) ng/ml. The serum level of GP73 stepwise increased with increase of liver inflammation grade and liver fibrosis stage, and GP73 was significantly correlated with liver inflammation grade (?=0.536, P<0.001) and fibrosis stage (?=0.536, P<0.001). The degree of liver inflammation or fibrosis at the same stage was analyzed and the results indicated that the serum GP73 levels were significantly correlated with the severity of liver inflammation, while the association between serum GP73 and the stage of liver fibrosis was weaker. In term of the advanced liver inflammation or fibrosis stage, univariate and multivariate analysis revealed that GP73 was simultaneously determined as an independent risk factor for predicting liver inflammation (P<0.001) and fibrosis (P<0.05). Conclusion Serum GP73 is well correlated with liver inflammation and fibrosis in CHB patients, and it might be a new biomarker to predict liver inflammation and fibrosis.