Immunologic Evaluation of Patients with Cefotetan-Induced Anaphylaxis
Allergy, Asthma & Immunology Research
;
: 301-303, 2015.
Article
in English
| WPRIM
| ID: wpr-85010
ABSTRACT
Cefotetan is a commonly prescribed second-generation cephalosporin that acts against a wide range of bacteria. However, cefotetan-induced hypersensitivity has rarely been reported. We report 2 cases of cefotetan-induced anaphylaxis with immunologic evaluation. The first case was a 70-year-old asthmatic woman who had dyspnea and hypotension during administration of cefotetan, in which high serum-specific IgE to cefotetan-human serum albumin (HSA) conjugate was detected by enzyme-linked immunosorbent assay. The second case was a 63-year-old asthmatic woman who complained of chest tightness and dyspnea during cefotetan infusion, in which high serum-specific IgG1 and IgG4 with no serum specific IgE to cefotetan-HSA conjugate was detected. The basophil activation test using basophils from the patient showed a significant up-regulation of CD63 with the addition of anti-IgG4 antibody compared with that in non-atopic healthy controls. In conclusion, cefotetan can induce anaphylaxis, which may involve both IgE- and IgG4-mediated responses in the pathogenic mechanism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thorax
/
Bacteria
/
Basophils
/
Immunoglobulin E
/
Immunoglobulin G
/
Serum Albumin
/
Enzyme-Linked Immunosorbent Assay
/
Cefotetan
/
Up-Regulation
/
Dyspnea
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2015
Type:
Article
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