Correlation of visceral adipose levels and cardiovascular risk factors for disease in patients with adult growth hormone deficiency / 解放军医学杂志

ABSTRACT

Objective To explore the correlation of visceral adipose index (VAI) with anthropometrics, glycolipid metabolism markers, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in patients with adult growth hormone deficiency (AGHD). Methods A total of 40 AGHD patients from First Affiliated Hospital of Chongqing Medical University and 40 healthy adults from physical examination centre (control group), matched with age and gender, were enrolled in present study. The general anthropometrics and blood biochemical indexes were collected and compared between the two groups. Waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), waist-height ratio (WHtR), and visceral adipose index (VAI) were examined, and homeostasis model assessment-insulin resistance (HOMA-IR), homeostasis model assessment β-cell function (HOMA-β), LDL-C/HDL-C, TC/HDL-C and TG/LDL-C between the two groups were calculated. Results Compared with control group, the levels of BMI, WC, WHR, fasting insulin (FINS), HOMA-β, HOMA-IR, triglyceride (TG), LDL-C/HDL-C, TC/HDL-C, hs-CPR, IL-6 and VAI were significantly higher, but those of HDL-C were lower in AGHD group (P<0.05). There was a positive correlation between VAI and all the factors including WC, WHR, FINS, HOMA-β, HOMA-IR, TC, LDL-C/HDL-C, TC/HDL-C, TG/LDL-C, hs-CRP and IL-6 (P<0.05). Multiple linear regression analysis revealed that hs-CRP and IL-6 were the independent risk factors of VAI. Pearson correlation index analysis showed that VAI was more correlated with lipid metabolism and inflammatory cytokines than with WC, BMI, WHR and WHtR. Conclusion VAI is significantly higher in AGHD patients than in healthy people, and it shows a strong correlation with many risk factors for cardiovascular diseases.