Effects of recombinant human growth hormone on the expression of CD47, L-selectin and advanced oxidation protein products in elderly patients with multiple organ dysfunction syndrome / 解放军医学杂志

ABSTRACT

Objective To investigate the effects of recombinant human growth hormone (rhGH) on the expression of CD47, L-selective action hormone (L-selectin), and advanced oxidation protein products (AOPPs) in elderly patients with multiple organ dysfunction syndrome (MODSE). Methods Sixty-six MODSE patients were randomly and equally divided into two groups (33 each) control group (received conventional treatment only) and rhGH treatment group (received conventional and rhGH treatment). Venous blood was taken from all the subjects before treatment and 3rd, 14th and 28th day after treatment. Serum CD47 was detected by flow cytometry, L-selectin and AOPPs concentrations were determined with ELISA and spectrophotometry. The changes in APACHE HI score in the two groups were also observed. Results Compared with that before treatment, the positive rate of CD47 was increased, meanwhile the AOPPs concentrations, L-selectin levels and APACHE HI scores declined markedly in both groups after treatment (P<0.05). Compared with that in control group, the positive rate of CD47 increased more significantly, while the AOPPs concentrations, L-selectin levels, APACHE HI scores and mortalities declined more significantly in rhGH treatment group (P<0.05). In the rhGH treatment group, the positive rate of CD47 increased, the AOPPs concentrations, while L-selectin levels and APACHE III scores declined markedly on the 14th day compared with those on the 3rd day, and on the 28th day as compared with that on the 14th day after treatment (P<0.05). ConclusionrhGH may enhance the immune function and reduce oxidative stress, inflammatory reaction, and mortality in elderly patients with MODSE.