Studies on the correlation between long-term blood pressure variability and leukoaraiosis / 解放军医学杂志

ABSTRACT

Objective To investigate the correlation between long-term blood pressure variability (BPV) and leukoaraiosis (LA). Methods Blood pressure was measured monthly in 209 patients visiting Zhejiang Hospital during June 2011 to June 2013, and they were followed up for 12 months. Te patients were divided into LA 0-3 groups according to the MRI results and Fazekas scale. Te clinical information, long-term blood pressure, and the index of long-term BPV were compared between LA groups and non-LA group, and among patients with different levels of LA, and then the correlation was regressively analyzed. Results One hundred and thirty-eight patients in LA group, and 71 in non-LA group. Regression analysis revealed that signifcant differences in age and the history of hypertension and occurrence of stroke between LA groups and non-LA group (P<0.05). Te maximal systolic blood pressure, the mean value of long-term blood pressure, the standard deviation (SD), coefficient of variation (C V), and variation independent of mean (VIM) of blood pressure were higher in LA groups than in non-LA group (P<0.05). Tere was signifcant difference in maximun systolic pressure between every level of LA groups (P<0.05). Te mean long-term systolic blood pressure and SD, CV and VIM of long-term blood pressure were signifcantly higher in the patients of LA3 group than that in the patients of LA1 group (P<0.05). Logistic regression analysis showed that the mean long-term diastolic blood pressure (OR=1.048, 95% CI 1.028-1.067), systolic blood pressure SD (OR=1.064, 95% CI 1.001-1.131), CV (OR=1.086, 95% CI 1.002-1.177), VIM (OR=1.060, 95% CI 1.001-1.122), and diastolic blood pressure SD (OR=1.111, 95% CI 1.000-1.233) and CV (OR=1.091, 95% CI 1.001-1.190) were the independent risk factors of LA (P<0.05). Conclusion Tere is a signifcant correlation between long-term diastolic blood pressure and long-term BPV and LA.