Advance in study of the relationship between cytoskeleton and the migration of trophoblast / 解放军医学杂志

ABSTRACT

The migration and invasion of trophoblast are closely associated with the cytoskeleton. The blocking of cytoskeleton's dynamic restructuring might inhibit the migration of the cell into the spiral artery and decidua, and it would lead to a shallow trophoblast implantation, ischemia and anoxia of placentome, and the occurrence of preeclampsia (PE) eventually. Shallow trophoblast implantation plays a key role in the development of PE, and the depth of implantation was shown to be directly related to the occurrence of PE. So the research in regard to the relationship between cytoskeleton and trophoblast's migration are of great significance for the understanding of the pathogenesis of PE. In recent years a number of studies on the role of cytoskeleton in shallow implantation have been reported from time to time, and their results will be analyzed comprehensively in the present article.