Analysis of the long term therapeutic effect of pre-operative installation of regional arterial infusion chemotherapy pump for advanced breast cancer / 解放军医学杂志

ABSTRACT

Objective To compare the long term therapeutic effects of the preoperative regional arterial infusion chemotherapy and the preoperative systemic venous chemotherapy in advanced breast cancer. Methods One hundred and eighty-six patients with advanced breast cancer, admitted to the Department of General Surgery of PLA 309 Hospital from Jan. 2003 to Dec. 2008, were followed up for a long time. Of them 97 patients received preoperative regional arterial infusion chemotherapy (IAIC groups), and 89 patients received preoperative systemic vein chemotherapy (IVIC groups). The local recurrence rate, distant metastasis rate, overall survival rate (OS) and disease free survival rate (DFS) in the two groups were statistically analyzed, and the long term therapeutic effects of the two groups were compared. Results There were no statistically significant difference in distant metastasis rate (15.5% and14.6%), 1-year OS (99.0% and 96.6%) and DFS (81.8% and 68.5%), and 3-year OS (88.7% and 79.8%) between the two groups (P>0.05). While significant differences were found between the two groups (P<0.01) in post-operative local recurrence rate (7.2% and 18.0%), 3-year DFS (70.1% and 52.8%), and 5-year OS and DFS. Conclusion Compared with preoperative systemic venous chemotherapy, pre-operative regional arterial infusion chemotherapy can decrease the local recurrence rate, improve the 5-year total survival rate and disease free survival rate for advanced breast cancer.