Correlation between atherogenic index of plasma level and metabolism components in adult growth hormone deficiency patients / 解放军医学杂志

ABSTRACT

Objective To investigate the correlation of atherogenic index of plasma (AIP) levels with anthropometrics, glycolipid metabolism markers and high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) in adult growth hormone deficiency (AGHD) patients. Methods Retrospective analysis were carried out in 40 AGHD patients (AGHD group, admitted to First Affiliated Hospital of Chongqing Medical University) and 40 healthy adults from physical examination centre (control group) during June 2009 to September 2012. The general anthropometries and blood biochemical indexes were collected and compared between two groups. AIP, homeostasis model assessment-insulin resistance (HOMA-IR), homeostasis model assessment β-cell function (HOMA-β), LDL-C/HDL-C, TC/HDL-C, and TG/LDL-C were calculated and compared between two groups. The correlation between AIP and these indexes was analyzed using Pearson correlation. Results Compared with control group, body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), fasting insulin (FINS), HOMA-P, HOMA-IR, total cholesterol (TC), triglyceride (TG), LDL-C/HDL-C, TC/HDL-C, hs-CPR, IL-6, AIP were significant higher, but HDL-C levels were lower in AGHD group (P0.05). There was a positive association between AIP and all the WC, WHR, FINS, HOMA- β, HOMA-IR, TC, \LDL-C/HDL-C, TC/HDL-C, TG/LDL-C, hs-CRP and IL-6 (r=0.349, 0.314, 0.347, 0.335, 0.297, 0.256, 0.576, 0.749, 0.702, 0.477, 0.226, respectively, P<0.05). Multiple linear regression analysis revealed that hs-CRP and IL-6 were independent risk factors of AIP. Conclusion AIP is significantly higher in AGHD patients than healthy people, and it shows a strong correlation with many risk factors for cardiovascular diseases.