To enhance evidence-based medical study of secondary brain injury factors / 解放军医学杂志

ABSTRACT

Objective To analyze the progress in evidence-based medical study on secondary brain injury factors during the past 10 years and propose the direction and focal points for future research in this field. Methods The achievements and latest tendency in the study of secondary brain injury factors during the last 10 years were retrieved from the literatures, and duly arranged and analyzed. Results Remarkable progress has been made in the study of secondary brain injury during the last 10 years. Many factors in the pathophysiological process participating in the production of second brain damage, such as hyperpyrexia, hypoxemia, hypotension, increased intracranial hypertension, decreased cerebral perfusion pressure, arrhythmia, electrolyte disturbances, acid-base imbalance, etc., have been identified. However, for the opportune time of monitoring secondary brain damage and the significance of these findings, further evidence-based study is still necessary. Conclusion The prevention and treatment of secondary brain injury induced by various brain damage factors are the keys to improving the level of treatment of severe brain injury.