Correlation between osteoprotegerin gene rs2073617T/C, rs2073618G/C polymorphism and acute coronary syndromes in Fujian Han population / 解放军医学杂志

ABSTRACT

Objective To study the genotype distribution and its association with acute coronary syndrome (ACS) of polymorphism of osteoprotegerin (OPG) gene promoter rs2073617T/C(950T/C) and the first exon rs2073618G/C(1181G/C) in Fujian Han population. Methods A total of seven hundred and twenty consecutive patients of unrelated Fujian Han people with ACS were enrolled in the present study. They were divided into ACS group and control group, 360 each. OPG gene 950T/C and 1181G/C were genotyped in all the patients using polymerase chain reaction restriction fragment length polymorphism (PCRRFLP). DNA sequences of enzyme digestion products were also analyzed. Results In Fujian Han population, the frequency of TC, TT, CC types of OPG 950T/C polymorphism in ACS patients and controls were 47.8%, 26.7% and 25.5% vs 43.3%, 33.3% and 23.3%; The frequency of GG, GC, CC types of OPG 1181G/C polymorphism in ACS patients and controls were 51.1%, 40.0% and 8.9% vs 60.0%, 35.0% and 5.0%. No significant differences were observed in the genotype and allelic frequency of OPG gene 950T/C and 1181G/C between the ACS and control groups. OPG gene 950T/C and 1181G/C showed no statistically significant difference between ACS patients with single-vessel, double-vessel and three or more-vessel disease. Conclusion OPG gene polymorphism of 950T/C and 1181G/C are not associated with ACS in Han population of Fujian.