Chemical constituents from whole plants of Scutellaria viscidula / 中草药

ABSTRACT

Objective: To investigate the chemical constituents from the whole plants of Scutellaria viscidula. Methods: By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20, the chemical constituents were isolated and purified. Their structures were elucidated by physico-chemical properties and spectral analyses. Results: A total of 22 compounds were isolated and identified as 5-hydroxy-7,8-dimethoxyflavone (1), chrysin (2), 5,7-dimethoxyflavone (3), 5,7,4’-trihydroxy- 6-methoxyflavone (4), 5,7,4’-trihydroxyflavonoid (5), 5,7,2’-trihydroxy-8-methoxyflavone (6), 5,7-dihydroxy-8,2’-dimethoxyflavone (7), 5,7,2’-trihydroxy-6-methoxyflavanone (8), 5-hydroxy-6,7,8-trimethoxyflavone (9), 5,6,7-trimethoxyflavone (10), 3,5-dimethoxy- 6,7-methylenedioxyflavone (11), 5,2’-dihydroxy-7,8,6’-trimethoxyflavone (12), 5,2’-dihydroxy-7,8,6’-trimethoxyflavanone (13), 5,7-dimethoxyflavanone (14), 7-methoxy-chrysin (15), 2’-hydroxy-5,7,8-trimethoxyflavone (16), ferulic acid (17), 4-hydroxy-3- methoxybenzoic acid (18), p-hydroxy-benzaldehyde (19), 3,5-dimethoxy-4-hydroxybenzoic acid (20), 7-hydroxy-6-methoxy-coumarin (21), 6,7-dihydroxyl-coumarin (22). Conclusion: Compounds 1, 3-16, 18 and 20 are isolated from Scutellaria viscidula for the first time.