A new amide compound from Onchidium verruculatum / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 5666-5669, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-850656
ABSTRACT
Objective:
To study the chemical composition of the marine characteristic resource, Onchidium verruculatum from Hainan Island.Methods:
Compound was separated and purified by silica gel and semi-preparative HPLC, detected by TLC, and identified by NMR and MS data. Compound 1 was evaluated for cytotoxic activity against four kinds of human tumor cell lines HepG-2, BEL-7042, A549, and MCF-7.Results:
A new amide compound, N-(2-hydroxy-4-methoxy-5-methylphenyl)formamide (1), was isolated from mucus and muscle tissue of O. verruculatum. The results showed that compound 1 has moderate toxic activity against A549 and BEL-7402 cell lines, with IC50 value of 11.5 μg/mL and 19.4 μg/mL.Conclusion:
Compound 1 is a new amide compound named onchumamide with moderate toxic activity on human tumor cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2019
Type:
Article
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