Advances in structural modification of matrine and its analogues / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 5892-5900, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-850686
ABSTRACT
Matrine is pyrrolizidine alkaloid derived from Chinese materia medica such as Sophora flavescens and Sophora alopecuroides. It has a wide range of pharmacological effects and abundant resources. Sophocarpine is a D ring 13,14-position dehydrogenation analogue of matrine. Due to the high similarity in structure, sophocarpine also exhibits a wide range of pharmacological activities. However, the pharmacological activities of matrine and sophocarpine are not strong, so a great scale of structural modification were carried out. In this paper, the structural modification and derivative activity of matrine and sophoridine were reviewed according to the modification sites classification, and the future development trend was prospected.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2019
Type:
Article
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