A Clinical Study of Children Who Showed Benign Hemophagocytic Histiocytes in Bone Marrow Examination
Journal of the Korean Pediatric Society
;
: 1007-1015, 2002.
Article
in Korean
| WPRIM
| ID: wpr-85070
ABSTRACT
PURPOSE:
The aim of this study is to find a method to diagnose and treat children who showed benign hemophagocytic histiocytes in bone marrow examination.METHODS:
We analyzed the clinical data of thirty patients retrospectively who showed benign hemophagocytic histiocytes in bone marrow examination from January 1995 to November 2001 at Keimyung University Dong-san Hospital. Bone marrow histiocytes were classified into a few, some, and many according to the number of histiocytes comparing with the white cells.RESULTS:
The age of thirty patients ranged from two months to 15 years. The median age was 5.6 years with male predominance(2.3 1). The most frequent clinical manifestation was fever; others were respiratory symptom, hepatosplenomegaly, lymphadenopathy and skin rash(in order of frequency). Common laboratory findings were leukopenia, thrombocytopenia, anemia and abnormal liver function test. Infection was present in 30 patients; causative organisms were documented in 15 patients, and bacterial infection was more common. Epstein Barr virus was the cause of infection in four patients. Bone marrow examination showed a few(20.0%), some(75.0%) and many(30.0%) hemophagocytic histiocytes. Combination immunochemotherapy including immunoglobulin, steroids and cyclosporine were helpful in 22 out of 30 patients. The mortality rate was high in young patients who showed some to many hemophagocytic histiocytes.CONCLUSION:
Bone marrow examinations and early detection of histiocytes will be helpful in children who have fever, hepatosplenomegaly and abnormal liver function test. Immunochemotherapy were helpful and further investigation will be needed for the detection of the relationship between the bone marrow findings and prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Skin
/
Steroids
/
Thrombocytopenia
/
Bacterial Infections
/
Bone Marrow
/
Bone Marrow Examination
/
Immunoglobulins
/
Retrospective Studies
/
Mortality
Type of study:
Observational study
/
Prognostic study
/
Screening study
Limits:
Child
/
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
2002
Type:
Article
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