Lignans from roots and rhizomes of Diphylleia sinensis / 中草药

ABSTRACT

Objective: To investigate the lignans of the roots of Diphylleia sinensis. Methods: The chemical components were isolated and purified by chromatographic techniques (silica gel, sephadex LH-20 and semi preparative-HPLC) and the chemical structures were determined by spectral data analysis (1D/2D NMR, MS, and IR). Results: Seven lignans were obtained and identified as diphyllin A (1), (1S,2R,5S,6R)-2-(4-hydroxyphenyl)-6-(3-methoxy-4-hydroxyphenyl)-3,7-dioxabicyclo [3.3.0] octane (2), (7S,8R,7’S,8’R)-3,4,3’,4’-tetramethoxy-9,7-dihydroxy-8.8’,7.O.9’-lignan (3), (-)-lariciresinol (4), vladinol D (5), podophyllotoxone (6), and justicidin A (7). Conclusion: Diphyllin A (1) is a new compound and 2-4 are obtained from D. sinensis for the first time.