Expression of GABA Transporters in the Rat's Olfactory Bulb during Development
Journal of Rhinology
;
: 24-29, 1999.
Article
in English
| WPRIM
| ID: wpr-85086
ABSTRACT
Developmental changes in the expression of two GABA (gamma-aminobutyric acid) transporter proteins, GAT-1 and GAT-3, in the olfactory bulb of embryonic and postnatal rats were examined with immunocytochemistry using antisera against GAT-1 and GAT-3. The expression and localization of GAT-1 and GAT-3 showed distinct temporal patterns during olfactory bulb development. GAT-1 immunoreactivity appeared weakly in most likely growing axons of the presumptive glomerular layer from embryonic day 18 and increased during the first postnatal week. In contrast, GAT-3 immunoreactivity, first detected at E16, was found in radial glial cell fascicles and was replaced by what were likely astroglial cells postnatally. At P7, GAT-1 and GAT-3 immunoreactivities reached the adult pattern i.e., GAT-1 immunoreactivity was observed in the labeled punctate structures in all layers of the olfactory bulb except the nerve fiber layer, while GAT-3 immunoreactivity was observed in the astroglial processes of all layers of the olfactory bulb. Our results suggest that GABA transporters, especially GAT-3, play important roles in regulating the GABA levels of developing olfactory bulbs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Olfactory Bulb
/
Axons
/
Immunohistochemistry
/
GABA Plasma Membrane Transport Proteins
/
Ependymoglial Cells
/
Gamma-Aminobutyric Acid
/
Immune Sera
/
Nerve Fibers
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Rhinology
Year:
1999
Type:
Article
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