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Optimization of extraction technology and inclusion process of volatile oil for Qingxiangrukang Granules based on Box-Behnken and PCA-G1-entropy method and orthogonal design / 中草药
Chinese Traditional and Herbal Drugs ; (24): 3631-3636, 2019.
Article in Chinese | WPRIM | ID: wpr-850952
ABSTRACT

Objective:

To optimize the extraction technology and inclusion process of volatile oil for Qingxiangrukang Granules (QG).

Methods:

Box-Behnken was used to optimize the extraction technology of volatile oil in QG. With yield of inclusion compound and inclusion rate of volatile oil-β-CD as evaluation indexes, and with volatile oil-pure water ratio, β-CD-volatile oil ratio, and inclusion time as investigate factors, the optimal inclusion technology for volatile oil of QG was ensured based on PCA-G1-entropy method and orthogonal design and by using colloid milling.

Results:

The optimum extraction technology of volatile oil were as follows extracting time was 6 h, liquid-material ratio was 10, immersion was 0 h. The optimal inclusion technology for volatile oil were as follows pure water-volatile oil ratio was 180, β-CD-volatile oil ratio was 6 g, and the inclusion time was 30 min. Under such condition, there was no significant difference between verification groups of three batches.

Conclusion:

This optimal extraction technology and inclusion process is stable and workable and can provide experimental basis for industrial production of QG.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2019 Type: Article